Dr. Santoshi Muppala

Instructor in Microbiology/Biotechnology/Molecular Biology                                  

                                                                                                                                                                         staff listing

Contact Information:

Department of Life Sciences
The University of The West Indies (UWI)
St. Augustine, Trinidad and Tobago

Location: 
Biochemistry Office, Room 217

Tel: (868) 662-2002 Ext. 83090

Send an e-mail

 
Education:
  • Post-doctoral Fellowship. (Molecular Cardiology), Cleveland Clinic, USA (2015)
  • Ph.D. (Molecular Cancer Biology), Heidelberg University, Germany (2013).
  • M.Sc. (Microbiology), Sri Venkateswara University, India (2003).
  • B.Sc. (Hons) (Microbiology), Sri Venkateswara University, India (2001).

Research Interests:

  • Identification of biomarkers (microRNAs) for diabetes patients.
  • Role of MicroRNAs in Colon/Breast cancer patients in Trinidad and Tobago.
  • Screening of novel antimicrobial compounds.

Invited Reviews:

  • MicroRNAs as Biomarkers and Prospective Therapeutic Targets in Colon and Pancreatic Cancers. Tumour Biology. 2015. Manuscript Number: TUBI-D-15-03251
  • Aquaporins: their role in gastrointestinal malignancies. Cancer Letters. 2015. Manuscript Number: CAN-D-15-02321
  • Rhamnolipid biosurfactant production by Pseudomonas aeruginosa strain KVD-HR42 isolated from oil contaminated mangrove sediments. Journal of Microbiology, Biotechnology and Food Sciences. 2015. Manuscript Number: JMBFS-0959
  • Inhibition of NF-κB translocation induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer. Cancer Letters. 2016. Manuscript Number: CAN-D-16-00077
Publications:    
  • Muppala S, Frolova E, Krukovets I, Plow EF and Stenina OI. 2015.“Regulation  of angiogenesis by TGFβ-thrombospondin-4 (TSP4) pathway”. Manuscript submitted to Journal of Experimental Medicine (JEM), under review.
  • Siva Krishna Prasad Konduru, Anthony Ameeral, Paramanand Maharaj, Santoshi Muppala, Bidyadhar Sa, T. Ramesh Rao and Suresh R. Rao. 2015. “Transabdominal and Transrectal Sonographic Variation of the Prostate volume and dimensions:In Evaluation of Benign Prostatic Hyperplasia”. British Journal of Medicine & Medical Research. 12(6): 1-8, 2016
  • Muppala S, Frolova E, Xiao R, Krukovets I, Yoon S, Hoppe G, Vasanji A, Plow E and Stenina-Adognravi O. 2015.  “Pro-angiogenic Properties of Thrombospondin-4”. Arterioscler Thromb Vasc Biol. ATVBAHA.115.305912.
  • Muppala S, Mudduluru G, Leupold JH, Buergy D, Sleeman JP, Allgayer H. 2013. “CD24 induces expression of the    Oncomir miR-21 via Src and both CD24 and Src are post-transcriptionally down-regulated by the tumor suppressor miR-34a”. Plos One: 8(3):e59563
  • Baumann P, Thiele W, Cremers N, Muppala S, Krachulec J, Diefenbacher M, Kassel O, Mudduluru G, Allgayer H, Frame M, Sleeman JP. 2011. “CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion”. Cell Mol Life Sci: 69(3):435-48
  • Regalla K, Mudduluru G, Ceppi P, Muppala S, Kozlowski M, Niklinski J, Papotti M, Allgayer H. 2011. “MiR-30 acts as an anti- metastatic microRNA and is down-regulated in non-small cell lung cancer”. Int J Cancer: 130(9):2044-53
  • Mudduluru G, George-William JN, Muppala S, Asangani AI, Regalla K, Nelson LD, Allgayer H. 2011. “Curcumin regulates miR-21 expression and inhibits invasion, metastasis in colorectal cancer”. Biosci Rep: 31(3):185-97
                                                                             

Revised: 3 March2016

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