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investigations demonstrate the important role of air traffic and also suggest that dengue geographic spread in the Americas is best described by a gravity model where larger more densely populated regions attract viruses from smaller less densely populated regions. Research findings suggest that efforts to understand dengue disease dynamics in the Caribbean need to focus at regionalrather than local scales and justify the roles of bodies like the Caribbean Public Health Agency CARPHA and the Pan American Health Organisation through which regional and country-based organi- zations co-ordinate their monitoring and control efforts. In contrast to the dengue viruses for yellow fever virus we noted significantly less viral traffic and strong evidence for in-situ maintenance of viruses between outbreaks. Our analyses confirmed that although there is occasional importation of yellow fever virus to Trinidad from the South American mainlandthe virus is maintained locally in Trinidad for relatively long periods.Further work is required to confirm the mechanism of yellow fever virus maintenance between outbreaks in order to fully understand the ecological factors influencing emergence and spread.Similarly for rabies virus we found evidence of at least three importations of the virus from the mainland within the last 40 years. We are now investigating the role of vampire bat movement between Trinidad and the mainland in rabies virus spread. One of my more recent interests is in using a metagenomics approach to define the viromesi.e.the genomes of all the viruses that inhabit a particular organismenvironment of species that are likely sources of potentially emergent viruses e.g. bats. Using a conventional PCR-based screening approach my group in collaboration with researchers in Hong Kong identified novel coronaviruses in Trinidad bats. I am also interested in host genetic factors that determine susceptibilityresistance to diseases in humans and have performed studies determining and comparing immune response gene in Trinidadians of African South Asian and Mixed descent. The results constitute baseline data for association studies for diseases such as dengue where the immune response is implicated in determining disease severity. The data also contrib- uted to studies led by Dr.Paul Norman at Stanford into the evolu- tion of specific immune response gene families. Im also currently involved in a study that seeks to determine genetic factors involved in eye disease. I have also been involved as a collaborator in studies that investigated non-viral infections. For example regarding the prevalence and molecular epidemiology of leptospirosis and malaria in Trinidad and Guyana respectively. The leptospirosis work led by Prof. A. Adesiyun also studied the efficacy of killed whole-cell vaccines developed from serovars isolated from Trinidad and compared with commercial vaccines using a hamster model. The results indicated better protection against circulating serovars using the in-house vaccine than with two commercial vaccines commonly used in Trinidad. Selected Publications CarringtonC.V.F.J.E.FosterO.G.PybusS.N.Bennett and E.C.Holmes. The invasion and maintenance of dengue virus type 2 and type 4 in the Americas.Journal of Virology2005792314680-14687. Allicock O.M P. Lemey A.J. Tatem O.G. Pybus S.N. Bennett B.A. MuellerM.A.SuchardJ.E.FosterA.Rambaut and C.V.F.Carrington. 173 Phylogeography and population dynamics of dengue viruses in the Americas. Molecular Biology and Evolution 2012 29 6 1533- 1543. Seetahal J.F. A. Velasco-Villa O.M. Allicock A.A. Adesiyun J. Bisses- sarK.AmourA.Phillip-HoseinD.A.MarstonL.M.McElhinneyM.Shi C.A.WharwoodA.R.Fooks and C.V.Carrington.Evolutionary history and phylogeography of rabies viruses associated with outbreaks in Trinidad.PLoS Neglected Tropical Diseases20132278.e2365. Website addresses for recent research projects Research gate profile httpwww.researchgate.netprofileChristine_Carrington2 Tropical Medicine ClusterInfectious Diseases.Member Profile httpsta.uwi.edutropicalmedicineccarrington.asp 60 under 60.Pelican Magazine Issue 5. httpssta.uwi.edupelican60under60ccarrington.asp Caribbean icons in sciencetechnology and innovation. httpwww.niherst.gov.tticonswomen-in-sciencechristine- carrington.html