Page 1
Page 2
Page 3
Page 4
Page 5
Page 6
Page 7
Page 8
Page 9
Page 10
Page 11
Page 12
Page 13
Page 14
Page 15
Page 16
Page 17
Page 18
Page 19
Page 20
Page 21
Page 22
Page 23
Page 24
Page 25
Page 26
Page 27
Page 28
Page 29
Page 30
Page 31
Page 32
Page 33
Page 34
Page 35
Page 36
Page 37
Page 38
Page 39
Page 40
Page 41
Page 42
Page 43
Page 44
Page 45
Page 46
Page 47
Page 48
Page 49
Page 50
Page 51
Page 52
Page 53
Page 54
Page 55
Page 56
Page 57
Page 58
Page 59
Page 60
Page 61
Page 62
Page 63
Page 64
Page 65
Page 66
Page 67
Page 68
Page 69
Page 70
Page 71
Page 72
Page 73
Page 74
Page 75
Page 76
Page 77
Page 78
Page 79
Page 80
Page 81
Page 82
Page 83
Page 84
Page 85
Page 86
Page 87
Page 88
Page 89
Page 90
Page 91
Page 92
Page 93
Page 94
Page 95
Page 96
Page 97
Page 98
Page 99
Page 100
Page 101
Page 102
Page 103
Page 104
Page 105
Page 106
Page 107
Page 108
Page 109
Page 110
Page 111
Page 112
Page 113
Page 114
Page 115
Page 116
Page 117
Page 118
Page 119
Page 120
Page 121
Page 122
Page 123
Page 124
Page 125
Page 126
Page 127
Page 128
Page 129
Page 130
Page 131
Page 132
Page 133
Page 134
Page 135
Page 136
Page 137
Page 138
Page 139
Page 140
Page 141
Page 142
Page 143
Page 144
Page 145
Page 146
Page 147
Page 148
Page 149
Page 150
Page 151
Page 152
Page 153
Page 154
Page 155
Page 156
Page 157
Page 158
Page 159
Page 160
Page 161
Page 162
Page 163
Page 164
Page 165
Page 166
Page 167
Page 168
Page 169
Page 170
Page 171
Page 172
Page 173
Page 174
Page 175
Page 176
Page 177
Page 178
Page 179
Page 180
Page 181
Page 182
Page 183
Page 184
Page 185
Page 186
Page 187
Page 188
Page 189
Page 190
Page 191
Page 192
Page 193
Page 194
Page 195
Page 196
Page 197
Page 198
Page 199
Page 200
Page 201
Page 202
Page 203
Page 204
Page 205
Page 206
Page 207
Page 208
Page 209
Page 210
Page 211
Page 212
186 Professor Nayak joined The University of the West IndiesFaculty of Medical Sciences as a lecturer. He was promoted to the rank of senior lecturer and then to professor in the years 2007 and 2012 respectively. The student community rated him with a consistent score of above 4.7 maximum 5.He received the UWIGuardian Life Premium Teaching Award in 2010.He is also a recipient of outstand- ing Preclinical Lecturer award from Trinidad and Tobago Medical Students Association 2013 and Movements for Encouragement and Dharmic Services Association 2011 and 2012. In 2013 he received the Vice Chancellors Award For Excellence In Teaching.He has written textbooks for medicaldentalnursing and allied health students.All these books have become popular among the student community in IndiaTrinidad and other countries. Professor Nayak is a renowned clinical biochemist and serves on the North Regional Health Authority as Honorary Consultant Biochemist.He is also a course convenor for MDSC 1101-Digestion and Metabolism.He is a chairman of the Ethics CommitteeFaculty of Medical Sciences. Research Accomplishments As a researcher Professor Nayak has published more than 85 articles in the area of type 2 diabetes and wound healing in national and international peer-reviewed journals. He has super- vised more than 20 medical student research groups thatwith his guidance were able to win the best research award in the Caribbean Health Research Council meeting and the Medical Sciences research day. Professor Nayak is an editorial member for more than eight international research journals and a reviewer for 30 international journals. Since 2005 he has individually and jointly attracted research grants worth TT 216000 from UWI Campus Research grants Caribbean Health Research Council and TT 44000 from the Trinidad and Tobago Government Research Grant. Research Summary Diabetes mellitus is a group of metabolic disorders characterized by hyperglycaemia with disturbances of carbohydrate fat and protein metabolism resulting from defects in insulin secretion insulin actionor both.Poor glycaemic controlobesity and lifestyle are some of the factors that have been implicated in the increased risk of cardiovascular disease amongst diabetic patients in the Trinidad population. Obesity is inversely related to adiponectin a protein that is synthesised exclusively in adipose tissue. Growing evidence suggests that adiponectin is an important determinant of insulin resistance since it acts either hormonally or locally on adipocytes to alter insulin signaling and influences glucose and lipid metabolism. Circulating levels of adiponectin are also associ- ated with better lipid profile particularly higher levels of HDL cholesterol and lower triglycerides decreased inflammation and improved glycaemic control. Chronic inflammation is thought to play a role in the pathogenesis of type 2 diabetes. Studies have shown a relationship between the onset of type 2 diabetes and various inflammatory markers including C-reactive protein CRP Interleukin IL-6 and Tumour Necrosis Factor alpha TNF- . The relationship of Inflammatory markers and other biochemical parameters with type 2 diabetes Professor Nayaks research group attempted to study the levels of inflammatory markers metabolic variables adiponectin and anthropometric variables and their relationship with the risk of type 2 diabetes.The results of their study have provided significant relationships between adiponectin and insulin resistance obesity and blood lipids. Abnormal lipid profile low levels of adiponectin and varied blood pressure are associated in Trinidadian type 2 diabetic subjects with regards to age gender and ethnicity. Adiponectin and TNF- appear to be related to differences in the insulin mediated glucose turnover. These findings if established can provide a useful tool for the clinician to prevent further progression of the diseases and complications that may arise. The research group have also investigated the association of creatinine and other demographic variables with the risk of developing type 2 diabetes. The data from their study showed an association of low serum creatinine abnormal lipid profile and demographic variables in type 2 diabetic Trinidadian subjects. The group also determined the relationship between RBC membrane and serum lipid composition in type 2 diabetes subjects with and without nephropathy. The data suggested that there is a relationship between RBC membrane and serum lipid composition in subjects with type 2 diabetes with and without nephropathy. This relationship shows that diet and lifestyle play a significant role in the alterations of the lipids both in serum and RBC membrane. Diabetes and microvascular complications Reseaech shows that increases in serum sialic acid and microalbu- min were strongly related to the presence of microvascular MEDICAL SCIENCES Professor of Biochemistry Department of Preclinical Sciences Tel 868 662 1873 ext. 4641 Mobile 868 720 2921 E-mail shivananda.nayaksta.uwi.edu PROF. SHIVANANDA NAYAK